Synthesis and Characterization of New Chlorhexidine-Containing Nanoparticles for Root Canal Disinfection
نویسندگان
چکیده
Root canal system disinfection is limited due to anatomical complexities. Better delivery systems of antimicrobial agents are needed to ensure efficient bacteria eradication. The purpose of this study was to design chlorhexidine-containing nanoparticles that could steadily release the drug. The drug chlorhexidine was encapsulated in poly(ethylene glycol)-block-poly(l-lactide) (PEG-b-PLA) to synthesize bilayer nanoparticles. The encapsulation efficiency was determined through thermogravimetric analysis (TGA), and particle characterization was performed through microscopy studies of particle morphology and size. Their antimicrobial effect was assessed over the endodontic pathogen Enterococcus faecalis. The nanoparticles ranged in size from 300-500 nm, which is considered small enough for penetration inside small dentin tubules. The nanoparticles were dispersed in a hydrogel matrix carrier system composed of 1% hydroxyethyl cellulose, and this hydrogel system was observed to have enhanced bacterial inhibition over longer periods of time. Chlorhexidine-containing nanoparticles demonstrate potential as a drug carrier for root canal procedures. Their size and rate of release may allow for sustained inhibition of bacteria in the root canal system.
منابع مشابه
The Effect of Sodium Hypochlorite and Chlorhexidine as Irrigant Solutions for Root Canal Disinfection: A Systematic Review of Clinical Trials.
INTRODUCTION This systematic review aimed to compare the effectiveness of sodium hypochlorite and chlorhexidine for root canal disinfection during root canal therapy. METHODS A literature search for clinical trials was made on the PubMed (MEDLINE), Web of Knowledge, SCOPUS, and Science Direct databases and in the reference lists of the identified articles up to January 2015. Quality assessmen...
متن کاملIn-Vitro Comparison of Antibacterial Efficacy of a New Irrigation Solution Containing Nanosilver with Sodium Hypochlorite and Chlorhexidine
Objective: Antibacterial properties of silver nanoparticles have recently come into the spotlight in endodontic therapy. This study was conducted aiming at comparing the antimicrobial activity of a new irrigation solution containing nanosilver particles with that of sodium hypochlorite and chlorhexidine against Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans...
متن کاملRoot canal disinfection of immature dog teeth with apical periodontitis: Comparison of three different protocols
OBJECTIVES The present in vivo study was designed to assess the efficacy of 3 root canal disinfection protocols in immature dog teeth with apical periodontitis (AP). MATERIAL AND METHODS Forty immature premolars with pulp necrosis and AP of five Beagle dogs were used. Three experimental disinfection protocols were established. After irrigation with 40 ml 5.25% sodium hypochlorite using the En...
متن کاملEvaluation and Comparison of Biological Cleaning Efficacy of Two Endofiles and Irrigants as Judged by Microbial Quantification in Primary Teeth — An In Vivo Study
The endodontic triad comprises of cleaning and shaping, disinfection and obturation. Success of root canal therapy is majorly achieved by proper cleaning and shaping. However, elimination of bacterial contaminants as well as necrotic debris of the canals requires the adjunctive use of irrigants. To achieve a satisfactory biological and mechanical preparation proper selection of endodontic instr...
متن کاملA comparison of chlorhexidine release rate from three polymeric controlled release drug prototypes
Complete debridement and thorough disinfection of infected root canals are considered mandatory for the success of root canal treatment. However, canal preparation and irrigation are not always effective in eliminating total microflora from the root canal system. Traditionally, calcium hydroxide has proven to be an excellent intracanal medicament for infected root canals. However, it is known t...
متن کامل